Article Text

Rare disease
Neuro-regression in vitamin B12 deficiency
  1. Sanwar Agrawal,
  2. Shweta Nathani
  1. Ekta Institute of Child Health, Pediatrics, Near Ram Mandir, Shantinagar, Raipur 492001, India
  1. Sanwar Agrawal, drsanwar50{at}


Neuroregression in infants has varied aetiology and vitamin B12 deficiency is one of the uncommon causes. Infantile vitamin B12 deficiency is encountered in malnourished infants or in offspring of strict vegan mothers. We present two cases, both infants of 10 and 8 months of age, whose mothers had vitamin B12 deficiency. On admission, the patients were apathic, hypotonic and lethargic. Serum vitamin B12 levels were below normal limits. On cranial MRI, T2-weighted images revealed frontoparietal cortical atrophy. Both the infants responded to vitamin B12 treatment.

View Full Text

Statistics from


  • Competing interests: none.

  • Patient consent: Patient/guardian consent was obtained for publication.

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.