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Unusual association of diseases/symptoms
A case of periodic fever and persistent splenomegaly in a 2-year-old boy
  1. Samson Chi Kwok1,
  2. Bruce H Bennetts2,
  3. Ralph Kay Nanan1
  1. 1
    University of Sydney, Department of Paediatrics, Nepean Clinical School, Derby Street, Penrith, New South Wales, 2750, Australia
  2. 2
    Children’s Hospital at Westmead, Department of Molecular Genetics, Hawkesbury Road, Sydney, New South Wales, 2145, Australia
  1. Samson Chi Kwok, kwoks{at}wahs.nsw.gov.au

Summary

We report an unusual case of periodic fever associated with persistent splenomegaly in a 2-year-old boy. Febrile episodes occurred at regular 2 weekly intervals and each lasted for 1–2 days. Following resolution of the fever on each occasion, the patient developed neck stiffness of 1–2 days duration. The periodic febrile episodes, as well as the splenomegaly, spontaneously resolved 9 months after the onset of disease. Infectious and malignant causes were ruled out as far as possible. This patient’s clinical features are unusual and do not match any known category of periodic fevers in childhood. We believe this case highlights the diagnostic challenges periodic fevers commonly represent.

https://doi.org/10.1136/bcr.06.2008.0098

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    Footnotes

    • Competing interests: none.

    • Patient consent: Patient/guardian consent was obtained for publication