Article Text

Unexpected outcome (positive or negative) including adverse drug reactions
New onset of multiple keratoacanthomas and palmoplantar hyperkeratosis caused by the treatment of metastatic renal cell carcinoma with a new generation multi-kinase inhibitor
  1. Jasper Mesarch1,
  2. John Rupp2,
  3. Nasir Zaidi3
  1. 1
    Madigan Army Medical Center, Bldg 9040, Fitzsimmons Dr, Ft Lewis, WA 98431, USA
  2. 2
    Dermatology Specialists Kc Inc, 1010 Carondelet Drive, Bldg A, Suite 125, Kansas City, MO 64114, USA
  3. 3
    Physicians Reference Laboratory, 7800 West 110th Street, Overland Park, KS 66210, USA
  1. Jasper Mesarch, jasper.mesarch{at}


The use of new generation multi-kinase inhibitors for the treatment of various malignancies has brought unique and previously unrecognised cutaneous reactions to the attention of dermatologists. We report the case of a patient with metastatic renal cell carcinoma who presented to our dermatology clinic with eruptive squamous cell carcinomas with keratoacanthomatous features and painless palmoplantar hyperkeratosis while taking sorafenib (Nexavar). Dermatological toxicity from sorafenib has been well described in the literature. Herein we describe a combination of unusual symptoms due to sorafenib.

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  • Competing interests: None.

  • Patient consent: Patient/guardian consent was obtained for publication.