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Rare disease
A case of Hashimoto encephalopathy in a Malay woman with Graves disease
  1. Chai Soon Ngiu,
  2. Norlinah M Ibrahim,
  3. Wan Nur Nafisah Wan Yahya,
  4. Hui Jan Tan,
  5. Norlaila Mustafa,
  6. Hamidon Basri,
  7. Raymond Azman Ali
  1. Hospital UKM, Department of Medicine, Jalan Yaacob Latiff, Kuala Lumpur, 56000, Malaysia
  1. Norlinah M Ibrahim, norlinah{at}


Hashimoto encephalopathy (HE) is a poorly recognised steroid-responsive encephalopathy, with prominent neuropsychiatric features. Diagnosis is often difficult due to its heterogeneous clinical presentation, especially since the thyroid status or anti-thyroid antibody titres may not be related to the disease state. Here, the case of a 23-year-old Malay woman with Graves disease who presented with progressive encephalopathy diagnosed as HE is presented. She responded dramatically to high dose intravenous and then oral corticosteroid. A month after the initiation of treatment, she regained full independency.

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  • Competing interests: None.

  • Patient consent: Patient/guardian consent was obtained for publication.

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