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Dermatology
Neonatal pemphigus vulgaris
  1. Sanmitra Aiholli1,
  2. Arun Inamadar2 and
  3. Ajit B Janagond3
  1. 1Dermatology, BLDE Deemed to be University, Vijayapura, Karnataka, India
  2. 2Department of Dermatology, Venereology and Leprosy, Shri BM Patil Medical College, Vijayapur, Karnataka, India
  3. 3Dermatology Venereology and Leprosy, Shri B M Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapur, Karnataka, India
  1. Correspondence to Dr Arun Inamadar; aruninamadar{at}gmail.com

Abstract

A neonate presented to a tertiary clinic with blisters and erosions over his trunk and extremities. The mother had multiple erosions with crusts affecting the scalp, oral cavity and trunk present since the first trimester and worse since delivery. Skin biopsy for histopathology and direct immunofluorescence confirmed pemphigus vulgaris (PV) in the mother. Indirect immunofluorescence assays for serum antibodies against desmogleins 1 and 3 were positive in both mother and baby confirming a diagnosis of neonatal PV. The baby’s lesions healed spontaneously within 2 weeks, and the mother was clear at 2 months following treatment with rituximab.

  • Dermatology
  • Obstetrics, gynaecology and fertility
  • Paediatrics (drugs and medicines)

https://doi.org/10.1136/bcr-2023-259305

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    Footnotes

    • X @Skin-Mitra, @ArunInamadar

    • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: SA, ABJ. The following author gave final approval of the manuscript: AI.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.