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Rheumatology
T-cell large granular lymphocytic leukaemia in rheumatoid arthritis
  1. Indira Acharya1,
  2. Lauren N Smith2,
  3. Bhaskar V Kallakury3 and
  4. Christopher Haas4,5
  1. 1Internal Medicine, MedStar Union Memorial Hospital, Baltimore, Maryland, USA
  2. 2Department of Rheumatology, Georgetown University School of Medicine, Washington, District of Columbia, USA
  3. 3Department of Pathology, MedStar Georgetown University Hospital, Washington DC, District of Columbia, USA
  4. 4Internal Medicine, MedStar Harbor Hospital, Baltimore, Maryland, USA
  5. 5MedStar Franklin Square Medical Center, Baltimore, Maryland, USA
  1. Correspondence to Dr Indira Acharya; acharyaindira99{at}gmail.com

Abstract

T-cell large granular lymphocytic (T-LGL) leukaemia is frequently associated with an autoimmune phenomenon; approximately one-third of patients have rheumatoid arthritis (RA). Intriguingly, one-third of patients with rheumatoid arthritis exhibit clonal T-cell patterns. Here, we present a patient with RA undergoing evaluation for neutropenia and splenomegaly who was later diagnosed with T-LGL leukaemia.

  • Autoimmunity
  • Haematology (incl blood transfusion)
  • Rheumatoid arthritis

https://doi.org/10.1136/bcr-2024-260470

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    Footnotes

    • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms and critical revision for important intellectual content: IA, LNS, BVK and CH. The following authors gave final approval of the manuscript: IA, LNS, BVK and CH.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.