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Endocrinology
Lipid apheresis in the management of severe hypertriglyceridaemia in an adolescent girl with global developmental delay
  1. Lara Al-Agailat1,
  2. Stephen Guertin2 and
  3. Elizabeth Littlejohn3
  1. 1Pediatrics, University of Michigan Health - Sparrow, Lansing, Michigan, USA
  2. 2Pediatrics - PICU, University of Michigan Health - Sparrow, Lansing, Michigan, USA
  3. 3Pediatrics and Human Development, Michigan State University and University of Michigan Health - Sparrow, East Lansing, Michigan, USA
  1. Correspondence to Dr Elizabeth Littlejohn; littl128{at}msu.edu

Abstract

Hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) remains one of the common metabolic causes of acute pancreatitis in the paediatric population and the third most common cause after alcohol and gallstones in the adult population. We report a case of an early adolescent girl with global developmental delay and moderate cognitive impairment of unknown aetiology who presented with recurrent acute pancreatitis and uncompensated hypovolaemic shock. She was found to have serum triglyceride level of 7877 mg/dL (reference range<150 mg/dL) and hyperglycaemia with ketosis (no prior history of diabetes mellitus) that was successfully treated with lipid apheresis. This sometimes is an early modality for treatment in adults; however, it remains a last resort in children, used only for severe cases. A brief literature review on severe HTG-AP and its management is also provided.

  • endocrine system
  • paediatrics (drugs and medicines)

https://doi.org/10.1136/bcr-2023-257587

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    Footnotes

    • Contributors All authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms and critical revision for important intellectual content. All authors gave final approval of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.