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Two cases of metastatic colorectal cancer with prolonged liver injury following capecitabine combination chemotherapy
  1. Takahiro Takada,
  2. Ryuji Katoh,
  3. Kazunosuke Yamada and
  4. Hitoshi Ojima
  1. Gastrointestinal Surgery, Gunma Prefectural Cancer Center, Ohta, Gunma, Japan
  1. Correspondence to Dr Takahiro Takada; ttakada{at}


We present two cases of metastatic colorectal cancer where a liver injury developed while receiving capecitabine. In both cases, the patients were switched from oral capecitabine to a continuous intravenous 5-fluorouracil infusion and were able to continue treatment without a relapse of hepatotoxicity.

  • Colon cancer
  • Chemotherapy

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  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms and critical revision for important intellectual content: TT, RK and KY. The following authors gave final approval of the manuscript: HO.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.