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Relapsing malignant phyllodes tumour presenting as isolated acrometastases
  1. Ellery H Reason1,
  2. Michael D Aiduk1,
  3. William C Eward2,3 and
  4. Laura H Rosenberger3,4
  1. 1Duke University School of Medicine, Durham, North Carolina, USA
  2. 2Department of Orthopaedics, Duke University, Durham, North Carolina, USA
  3. 3Duke Cancer Institute, Durham, North Carolina, USA
  4. 4Surgery, Duke University Health System, Durham, North Carolina, USA
  1. Correspondence to Dr Laura H Rosenberger; laura.rosenberger{at}duke.edu

Abstract

Malignant phyllodes tumours (PTs) are aggressive neoplasms with high rates of local recurrence and distant metastasis. With no known effective chemotherapy and no approved targeted therapy in the setting of metastatic disease, prognosis is limited with an often-relapsing course of disease. We report a case of a woman in her late 30s with a diagnosis of recurrent metastatic malignant PT who was found to have acrometastases of the malignant PT to the right distal index and small digits. We emphasise the potential for atypical patterns of metastases in patients with malignant PT and the need to recognise acrometastasis as an unusual but morbid manifestation of disease. Given the high growth rate of malignant PTs, the lack of systemic treatment options, and the ensuing distress for patients, prompt diagnosis and early intervention is crucial.

  • Cancer intervention
  • Dermatology
  • Breast cancer
  • Orthopaedics
  • Palliative procedures

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Footnotes

  • X @RosenbergerMD

  • Contributors EHR: Conceptualisation, methodology, writing of the original draft, review and editing, visualisation, supervision, final approval and accountability. MDA: Methodology, writing of the review and editing, final approval and accountability. WCE: Conceptualisation, methodology, writing of the review and editing, supervision, final approval and accountability. LHR: Conceptualisation, methodology, writing of the original draft, review and editing, visualisation, supervision, final approval and accountability.The following authors gave final approval of the manuscript: EHR, MDA, WCE, LHR.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.