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Extranodal diffuse large B-cell lymphoma involving the uterine cervix
  1. Anu Ajakaiye1,
  2. David Watson2,
  3. Huyam Abdelsalam2 and
  4. Aderemi Alalade3
  1. 1Obstetrics and Gynaecology, Cardiff and Vale University Health Board, Cardiff, UK
  2. 2Pathology, Betsi Cadwaladr University Health Board, Wrexham, UK
  3. 3Obstetrics and Gynecology, Betsi Cadwaladr University Health Board, Wrexham, UK
  1. Correspondence to Dr Anu Ajakaiye; anu.ajakaiye{at}


This is a case of primary diffuse large B-cell lymphoma involving the uterine cervix which presented with irregular vaginal bleeding. The diagnosis was confirmed following multiple cervical biopsies. Treatment with a combination of immunotherapy, chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP)) and radiotherapy produced a good response.

  • Cervical cancer
  • Gynecological cancer
  • Haematology (incl blood transfusion)

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  • X @HuyamDR

  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: DW and AAl edited the manuscript. HA provided the histology images and description. AAj researched and drafted the manuscript. AAl gave final approval of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.