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Intracardiac diffuse large B-cell lymphoma: an unexpected diagnosis
  1. Komeil Alattar1,
  2. Sagar Dodhia1,
  3. Chieh-Yin Huang1,
  4. Joana Briosa Neves2 and
  5. Arafat Haris1
  1. 1 Darent Valley Hospital, Dartford, UK
  2. 2 Guy's and St Thomas' NHS Foundation Trust, London, UK
  1. Correspondence to Dr Komeil Alattar; komeil.alattar1{at}


Intracardiac lymphomas are exceedingly rare accounting for only 1% of all primary cardiac tumours. Historically, due to their insidious development and non-specific clinical presentation, the diagnosis has been challenging with most cases being confirmed on post-mortem examination. Our case report details the experience of a previously fit and active woman in her 60s who presented with gradual onset exertional dyspnoea. Through a series of multimodal imaging tools (including echocardiogram, cardiac MRI, CT and positron emission tomography-CT) and biopsy, we confirmed the diagnosis of intracardiac diffuse large B-cell lymphoma. Our patient was managed with chemotherapy and went on to demonstrate excellent radiological response with near-complete resolution of the intracardiac mass. Subjectively, our patient reported significant improvement in exercise tolerance within weeks of commencing treatment.

  • oncology
  • radiology

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  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: KA, SD, C-YH, AH, JBN. The following authors gave final approval of the manuscript: KA, SD, C-YH, AH, JBN.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.