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TET2-mutant undifferentiated pleomorphic sarcoma metastatic to lung and brain
  1. Sophia Wix1,
  2. Winston Scambler1,
  3. Vinh Trang2 and
  4. Rehan A Malik1
  1. 1 Texas Christian University Anne Burnett Marion School of Medicine, Fort Worth, Texas, USA
  2. 2 Texas Oncology, Fort Worth, Texas, USA
  1. Correspondence to Dr Rehan A Malik; dr.ramalik{at}


Sarcomas constitute approximately 1% of adult cancers and 8%–10% of paediatric cancers. Undifferentiated pleomorphic sarcoma (UPS) is a type of soft-tissue sarcoma (STS) characterised by dedifferentiated cancer cells. The most common sites of metastasis for UPS include the lungs, liver, bones and regional lymph nodes. Brain metastasis is rare, affecting only 1%–8% of STS patients. This report presents a unique case of a woman in her 80s with a TET2-mutant UPS metastatic to the lung and brain.

  • Neurosurgery
  • Pathology
  • Oncology
  • Neurology
  • Genetics

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  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: SW, WS, VT and RM. The following author gave final approval of the manuscript: RM.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.