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Extraneural metastatic ependymoma: distant metastasis to the pleura, lungs, lymph nodes and bone
  1. Mina Guirguis1,
  2. Zhixin Jiang1,
  3. Chunyu Cai2 and
  4. Michael Youssef1
  1. 1Department of Neurology, UT Southwestern Medical Center, Dallas, Texas, USA
  2. 2Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA
  1. Correspondence to Dr Michael Youssef; michael.youssef{at}


Ependymomas are neuroepithelial tumours arising from ependymal cells surrounding the cerebral ventricles that rarely metastasise to extraneural structures. This spread has been reported to occur to the lungs, lymph nodes, liver and bone. We describe the case of a patient with recurrent CNS WHO grade 3 ependymoma with extraneural metastatic disease. He was treated with multiple surgical resections, radiation therapy and salvage chemotherapy for his extraneural metastasis to the lungs, bone, pleural space and lymph nodes.

  • Neurooncology
  • Cancer intervention

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  • Contributors MG, ZJ, CC and MY were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing of original diagrams and algorithms and critical revision for important intellectual content. MG, ZJ, CC and MY gave final approval of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.