Article Text

Download PDFPDF
Follow-up report of fundus findings of tuberous sclerosis-associated retinal astrocytoma of two siblings
  1. Anand Naik Bukke,
  2. Dheepak M Sundar,
  3. Rohan Chawla and
  4. Chandradevi Shanmugam
  1. Department of Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, Delhi, India
  1. Correspondence to Dr Anand Naik Bukke; naikanand6461{at}gmail.com

Abstract

A late adolescent with tuberous sclerosis (TS) presented with reduced vision in one eye to our tertiary care university hospital 4 years ago. Fundus examination revealed multiple retinal astrocytic hamartomas (RAHs) in both eyes. His younger sibling, who also had TS, was found to have RAH on retinal screening. The swept-source optical coherence tomography (SS-OCT) findings were typical of RAH. We further noted that some of the RAH lesions showed segmental whitening of the outer walls of the arterioles, which traversed through them. The segmental whitening may suggest the enveloping of normal retinal vessels by the tumour. En-face and B-scan SS-OCT angiography of patients with TS showed vascularity within the tumour. The vessels within the tumour appeared to be in continuity with the retinal vasculature. Both siblings were reviewed annually. At the end of 4 years, there was no change in visual acuity, tumour size, number, vascularity and behaviour.

  • ophthalmology
  • retina

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Footnotes

  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: ANB was involved in image acquisition, data collection, manuscript drafting, preparation, intellectual input and patient’s follow-up examinations, finalisation of manuscript and upload; DMS was involved in manuscript preparation, intellectual input and finalisation of the manuscript and patient’s follow-up; RC was involved in manuscript finalisation and intellectual input; CS was involved in image preparation and intellectual input of the manuscript. The following author gave final approval of the manuscript: RC.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.