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Mycobacterium senegalense catheter-related bloodstream infection
  1. Noralwani Badarol Hisham1,2,
  2. Mazriza Madon2,
  3. Siti Norbaya Masri1,3 and
  4. Syafinaz Amin-Nordin1,3,4
  1. 1 Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
  2. 2 Department of Pathology, Hospital Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia
  3. 3 Hospital Sultan Abdul Aziz Shah, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
  4. 4 Institute of Bioscience, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
  1. Correspondence to Dr Syafinaz Amin-Nordin; syafinaz{at}


Catheter-related bloodstream infection (CRBSI) is one of the common healthcare-acquired infections imposing a high burden of morbidity and mortality on the patients. Non-tuberculous mycobacterium is a rare aetiology for CRBSI and poses challenges in laboratory diagnosis and clinical management. This is a case of a woman in her early 60s with underlying end-stage renal failure, diabetes mellitus and hypertension presented with a 2-week history of high-grade fever postregular haemodialysis, vomiting, lethargy and altered mental status.

Blood cultures from a permanent catheter and peripheral taken concurrently yielded Mycobacterium senegalense, identified by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry, which established the diagnosis of CRBSI atypically presented with concurrent acute intracranial bleeding and cerebrovascular infarction at initial presentation. She was started on a combination of oral azithromycin, oral amikacin and intravenous imipenem, and the permanent catheter was removed. Despite the treatments instituted, she developed septicaemia, acute myocardial infarction and macrophage activation-like syndrome, causing the patient’s death.

  • Nosocomial infections
  • Chronic renal failure

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  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: NBH, SAN. The following authors gave final approval of the manuscript: NBH, SAN, SNM, MM.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.