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Atypical parathyroid adenoma with severe bone manifestations in early adolescence
  1. Ana Rachel Teixeira Batista Carvalho1,
  2. Paula Hollanda de Araújo1,
  3. Flaviene Alves do Prado Romani1 and
  4. Betânia Bisinoto Barra2
    1. 1Endocrinology, Hospital Regional de Taguatinga, Taguatinga, Brazil
    2. 2Pediatric Endocrinology, Hospital Regional de Taguatinga, Taguatinga, Distrito Federal, Brazil
    1. Correspondence to Dr Ana Rachel Teixeira Batista Carvalho; anarachel_t{at}


    This is a case of primary hyperparathyroidism in a female teenager with multiple fractures and severe bone manifestations. The histopathology revealed atypical parathyroid adenoma, an exceedingly rare form of hyperparathyroidism; its main differential diagnosis is parathyroid carcinoma, as it shares both clinical and histological characteristics with it, in addition to its still uncertain malignant potential.

    • Calcium and bone
    • Paediatrics
    • Endocrine cancer

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    • Contributors ARTBC, BBB, PHA, FAPR were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, and critical revision for important intellectual content. All authors gave their final approval of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.