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Dermatofibrosarcoma protuberans of the breast
  1. Muskaan Qadir1,
  2. Saira Fatima2,
  3. Safdar Shaikh3 and
  4. Sana Zeeshan3
  1. 1Medical College, Aga Khan University, Karachi, Pakistan
  2. 2Pathology, Aga Khan University, Karachi, Sindh, Pakistan
  3. 3Surgery, Aga Khan University, Karachi, Pakistan
  1. Correspondence to Dr Sana Zeeshan; sana.zeeshan{at}


Dermatofibrosarcoma protuberans (DFSP) of the breast is an infrequent soft tissue sarcoma that usually affects young to middle-aged women. Our case report describes a unique occurrence of DFSP of the breast in an adolescent girl, which was initially being managed as a keloid for 2 years under dermatology despite being refractory to treatment. Once the diagnosis of DFSP was confirmed through punch biopsy, our patient underwent surgical excision of the lesion under general anaesthesia. Our patient was at an increased risk of damage to the ductal system due to proximity of the lesion to the nipple–areolar complex, warranting the need for early recognition and treatment. As demonstrated by our case, DFSP of the breast can be difficult to diagnose since it resembles a range of benign and malignant pathologies of the breast.

  • Breast surgery
  • Skin cancer
  • Pathology
  • Plastic and reconstructive surgery

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  • X @Dr_SanaZeeshan

  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content—SZ, SS, SF and MQ. The following authors gave final approval of the manuscript—SZ, SS and SF.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.