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Congenital brain tumour in a neonate: a therapeutic challenge
  1. Praneetha Mude1,
  2. Monalisa Pradhan1,
  3. Anuj Tiwari2,
  4. Tapas Kanti Parida3,
  5. Manoj Kumar Nayak4,
  6. Arun Kumar Sekar2,
  7. Suvendu Purkait3 and
  8. Usha Devi1
  1. 1Neonatology, AIIMS Bhubaneswar, Bhubaneswar, India
  2. 2Neurosurgery, AIIMS Bhubaneswar, Bhubaneswar, India
  3. 3Pathology, AIIMS, Bhubaneswar, India
  4. 4Radiology, AIIMS, Bhubaneswar, India
  1. Correspondence to Dr Usha Devi; dr.ushaa{at}


A term neonate with history of ventriculomegaly in the fetal period was diagnosed with a central nervous system tumour after radiological investigations. It was confirmed as an immature teratoma after histopathological examination. He underwent left frontal craniotomy with tumour excision. Intraoperatively, massive haemorrhage (venous bleed) occurred due to the high vascularity of the tumour and led to haemodynamic instability. A massive transfusion protocol was initiated. Despite multiple transfusions and shock management, he succumbed at 2 weeks of life. This case report highlights the importance of antenatal diagnosis and fetal MRI in prognostication and also the possible role of neoadjuvant chemotherapy in reducing tumour vascularity and, hence, bleeding.

  • Hydrocephalus
  • Neonatal intensive care

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  • Contributors PM, MP, AT, MKN, AKS and UD were involved in the clinical management of the patient. AT and AS performed the surgical procedure. TKP and SP were involved in histopathological examination and definitive diagnosis. PM, MP, AT and TKP were responsible for drafting the text and sourcing. MKN, AKS, SP and UD edited clinical images and performed critical revisions for important intellectual content. All authors contributed equally to this manuscript, reviewed the final manuscript and gave final approval.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.