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Gastroenterology
Mercaptopurine-induced Sweet’s syndrome
  1. Natalie Commins1,
  2. Deloshaan Subhaharan1,
  3. Andrew Dettrick2 and
  4. Desmond Patrick1
  1. 1Department of Gastroenterology, Sunshine Coast University Hospital, Birtinya, Queensland, Australia
  2. 2Department of Pathology, Pathology Queensland, Birtinya, Queensland, Australia
  1. Correspondence to Dr Natalie Commins; natalie.commins{at}gmail.com

Abstract

Sweet’s syndrome is an acute febrile neutrophilic dermatosis. Drug-induced Sweet’s syndrome typically occurs soon after drug administration, with rapid resolution of symptoms with cessation of the offending agent. We report a man in his early 40s who presented with fever and widespread erythematous rash on a background of recently diagnosed mild stricturing ileal Crohn’s disease. He was commenced on 6-mercaptopurine 12 days before presentation. Skin biopsy demonstrated diffuse infiltration of neutrophils in the upper dermis, dermal oedema, eosinophils and fibrin deposition. Symptoms rapidly improved with cessation of 6-mercaptopurine without requiring systemic corticosteroids.

  • crohn's disease
  • inflammatory bowel disease
  • dermatology
  • gastrointestinal system
  • unwanted effects / adverse reactions

https://doi.org/10.1136/bcr-2023-259278

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    Footnotes

    • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: NC, DS, AD, DP. The following authors gave final approval of the manuscript: NC, DS, AD, DP.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.