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Triad of cluster-like headaches, hypertension and hypercoagulability a pointer to pheochromocytoma
  1. Archana Rampuria1,
  2. Thomas Mathew2 and
  3. Aditya Honnali Ravindranath2
  1. 1Dept of Medicine, St John's National Academy of Health Sciences, Bangalore, Karnataka, India
  2. 2Dept of Neurology, St John's National Academy of Health Sciences, Bangalore, Karnataka, India
  1. Correspondence to Dr Thomas Mathew; chakkuthom{at}hotmail.com

Abstract

We report the case of a middle-aged hypertensive woman presenting to the neurology department with short-lasting episodic headaches for 4 years. She was initially diagnosed and treated with cluster headaches for one year. Following this, she presented with right lower limb arterial claudication. Arterial Doppler of lower limbs showed thrombosis of the bilateral common femoral arteries. Further computed tomography (CT) angiogram of the lower limbs confirmed extensive arterial thrombosis in bilateral lower limbs. The CT angiogram incidentally detected a left adrenal lesion. She had elevated urinary vanillylmandelic Acid and 24-hour metanephrines suggesting the presence of a pheochromocytoma. She was initially medically managed and later underwent left open adrenalectomy. Histopathology examination of the sections proved pheochromocytoma. Postsurgery, the patient’s symptoms improved remarkably. This case highlights the importance of diagnosing pheochromocytoma when you encounter a patient with refractory short-lasting headaches, hypertension and hypercoagulability.

  • Thrombosis
  • Headache (including migraines)
  • Hypertension
  • Adrenal disorders
  • Endocrine cancer

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Footnotes

  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: AR, TM and AHR. The following authors gave final approval of the manuscript: TM.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.