You are here

Article Text

Article menu
Download PDFPDF
Haematology
Possible case of bortezomib-induced ileus paralytic
  1. Nikhil Aravind1,
  2. Niveditha Krishnappa1,
  3. Nusrat Shafiq1 and
  4. Pankaj Malhotra2
  1. 1Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
  2. 2Hematology, Internal Medicine, PGIMER, Chandigarh, India
  1. Correspondence to Dr Pankaj Malhotra; hematpgi{at}gmail.com

Abstract

This report describes a case of a patient with active multiple myeloma who was started on bortezomib, cyclophosphamide and dexamethasone and subsequently presented to the emergency department with acute intestinal obstruction one week later. The patient underwent exploratory laparotomy, but no mechanical cause of the obstruction was found. The patient later developed sepsis and eventually died. The possible cause of the intestinal obstruction was attributed to bortezomib, and the paper discusses the potential mechanism of this side effect and its management based on available literature.

  • Unwanted effects / adverse reactions
  • Haematology (incl blood transfusion)
  • Malignant and Benign haematology
  • Chemotherapy

https://doi.org/10.1136/bcr-2023-257592

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: NA, NK, NS and PM. The following author gave final approval of the manuscript: PM.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.