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Atypical organophosphate poisoning and a successful case of prolonged intubation in a low-resource newly developed intensive care unit in rural Zambia
  1. Lara Bowell1 and
  2. Mark Timothy Williams2
  1. 1Intensive Care Unit, Katete, Zambia
  2. 2General Practice - Global Health Fellow, NELFT NHS Foundation Trust, Rainham, UK
  1. Correspondence to Dr Mark Timothy Williams; drmarkwilliams{at}icloud.com

Abstract

Organophosphate poisoning is a common, under-reported cause of attempted and completed suicide worldwide. Following the resolution of the acute cholinergic syndrome, patients may develop respiratory muscle and proximal limb weakness, known as intermediate syndrome. A young man was brought to our rural hospital unconscious, in extremis, due to organophosphate pesticide poisoning. He developed atypical intermediate syndrome with global paralysis, persistent fasciculations and prolonged cholinergic symptoms, differing from the recognised presentation. He was intubated for fifteen days in our newly developed intensive care unit. Limited treatment options and the absence of blood gases, electrolyte testing, ECGs, invasive monitoring and imaging, in conjunction with regular disruptions to electricity and oxygen, and complications including seizures and pneumonia, all made this prolonged intubation an ambitious and challenging endeavour. We offer learning points for the acute physician and rural intensivist, and a summary of our reflections and hints for best care when adapting to a resource-limited setting.

  • Toxicology
  • Adult intensive care
  • Neuromuscular disease
  • Poisoning

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Footnotes

  • Contributors LB and MTW are the joint and sole authors of this case report. LB conceived the report. LB and MTW jointly researched, referenced, wrote and edited the case report. MTW is corresponding author.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.