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Parathyroid carcinoma in a patient with primary hyperparathyroidism mimicking parathyroid adenoma
  1. Nidhi Anand1,
  2. Ruchita Sachan1,
  3. Mallika Dhanda2 and
  4. Nuzhat Husain1
  1. 1Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India
  2. 2Endocrine Surgery, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, India
  1. Correspondence to Dr Nidhi Anand; nidhi.anand42{at}


Primary hyperparathyroidism caused by parathyroid carcinoma is extremely rare. Clinically, it is very challenging to differentiate between parathyroid carcinoma and adenoma. The correct diagnosis is made based on the histopathology of the resection specimen. This case report presents a woman in her 40s with body aches, knee joint pain, and fatigue, along with chronic kidney disease. Ultrasonography revealed a large hyperechoic lesion in the left parathyroid gland. Serum calcium, parathyroid hormone, urea, and creatinine levels were increased. The inferior parathyroid gland was surgically removed, and histopathological evaluation confirmed a diagnosis of parathyroid carcinoma. Unfortunately, many patients do not undergo complete resection due to a lack of a correct diagnosis during the initial surgery.

  • Pathology
  • Calcium and bone
  • Endocrine cancer

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  • Contributors NA, RS, and MD were responsible for the drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content. NH gave final approval of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.