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Coexistence of Rosai-Dorfman disease and Hodgkin’s lymphoma in a patient with cervical lymphadenopathy
  1. Elena González Turienzo1,
  2. Felipe Domínguez Celis1,
  3. Paula Martínez Ruiz de Apodaca1 and
  4. Francisco Pons Rocher1,2
  1. 1Otorrinolaringología, Hospital Universitario Doctor Peset, Valencia, Spain
  2. 2Cirurgia (Otorhinolaryngology), Universitat de Valencia Facultat de Medicina i Odontologia, Valencia, Spain
  1. Correspondence to Dr Francisco Pons Rocher;{at}


A man in his 40s, with no tobacco or alcohol habit, was referred to the otorhinolaryngology department presenting with a 2-month history of enlarged left cervical lymphadenopathy with no other signs or symptoms. The ear, nose and throat examination showed no abnormalities apart from the described lymphadenopathy. An ultrasound scan suggested these nodes to be part of either an inflammatory or a malignant process. Subsequent positron emission tomography-CT proved those lymph nodes to be metabolically active, as well as others within the thorax. Cervicotomy was performed and the histopathological analysis showed dilated sinuses and histiocytes with emperipolesis. Suspecting Rosai-Dorfman disease (RDD), high-dose steroid therapy was started; but given no improvement was observed, a second cervicotomy was performed, with the histopathological diagnosis of the latter of Hodgkin’s lymphoma. The present article aims to emphasise the need to exclude haematological disorders whenever RDD histology is observed, given their possible coexistence, and a worse outcome and clinical and histopathological semblance.

  • Haematology (incl blood transfusion)
  • Pathology
  • Otolaryngology / ENT
  • Head and neck surgery

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  • Contributors EGT—conceptualisation, clinical information collection, manuscript writing and English editing. FDC—published literature review and multimedia work. PMRdA—conceptualisation, patient intervention, published literature review and manuscript review. FPR—multimedia work and manuscript review.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.