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Rare case of primary bone lymphoma of the femur
  1. Amy Kiamos1,
  2. Kimberly Boldig1,
  3. Vinay Gagadam2 and
  4. Rahul Gujarathi2
  1. 1Internal Medicine, University of Florida College of Medicine, Jacksonville, Florida, USA
  2. 2Hospital Medicine, University of Florida Health Science Center, Jacksonville, Florida, USA
  1. Correspondence to Dr Amy Kiamos; amy.kiamos{at}


Primary bone lymphoma is a rare type of lymphoma that arises from skeletal tissue. Most cases described are non-Hodgkin’s lymphoma with diffuse large B-cell lymphoma being the most common subtype. While it is common for non-Hodgkin’s lymphoma to have secondary skeletal system involvement, primary involvement of the skeleton is surprisingly rare. Primary bone lymphoma accounts for less than 5% of all primary bone malignancies, 4%–5% of extranodal lymphomas and less than 1% of all non-Hodgkin’s lymphoma. We present an interesting case of a young adult male who was diagnosed with primary bone lymphoma of the femur. Interestingly, his initial X-ray imaging revealed no osseous abnormality and subsequent MRI revealed an infiltrating mass. The patient was treated with chemotherapy of rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone resulting in complete remission.

  • Malignant and Benign haematology
  • Oncology
  • Chemotherapy
  • Orthopaedics

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  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: AK, KB, VG, RG. The following authors gave final approval of the manuscript: AK, KB, VG, RG.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.