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Euvolaemic hyponatraemia as a rare first presentation of chronic hypopituitarism
  1. Calvin Coe1,
  2. Susan Vincy Mathew2 and
  3. Edward B Jude3,4
  1. 1Tameside and Glossop Integrated Care NHS Foundation Trust, Ashton-under-Lyne, UK
  2. 2Department of Diabetes and Endocrinology, Tameside General Hospital, Ashton-under-Lyne, UK
  3. 3Department of Biomolecular Science, University of Manchester Institute of Science and Technology, Manchester, UK
  4. 4Faculty of Science and Engineering, Manchester Metropolitan University, Manchester, UK
  1. Correspondence to Dr Edward B Jude; edward.jude{at}


A man in his late 40s with no significant medical history presented with 2 weeks of lethargy, nausea and dizziness, alongside worsening headaches. Initial assessment revealed severe hyponatraemia and secondary hypothyroidism; urgent MRI pituitary was requested with a clinical suspicion of pituitary apoplexy. This demonstrated a likely cystic pituitary adenoma, with further testing revealing pituitary gland suppression, leading to a diagnosis of chronic secondary hypopituitarism. Initiating hormone replacement allowed substantial reported improvements in this patient’s quality of life.

A review of the patient’s work-up revealed areas in which best practice was not followed. Cortisol measurements and paired urinary and serum osmolalities were initially not sent, nor results appropriately chased. A subsequent literature review identified that conformation with national and local guidelines on hyponatraemia management is poor. This patient’s case, when combined with the literature review, provides evidence to support methods to increase educational awareness of an appropriate work-up of hyponatraemia among clinicians.

  • Pituitary disorders
  • CNS cancer

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  • Contributors EJ, SVM and CC were directly involved in the patient’s care. EJ is the clinician in charge of the clinical care of the patient, who supervised the preparation of the manuscript, was responsible for obtaining informed consent from the patient/guardian/family members and is responsible for the overall integrity of the content of the manuscript. CC, SVM and EJ were responsible for drafting of the text, sourcing and editing of clinical images, investigation results and critical revision for important content. CC, SVM and EJ gave approval of the final manuscript. The patient is NOT one of the authors of this manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.