Article Text

Download PDFPDF
Metastatic HER2 lacrimal/salivary gland duct adenocarcinoma
  1. Ruaa Abdullah Mansi1,
  2. Bríd Morris2,
  3. Tim Fulcher2 and
  4. John H. McDermott3
  1. 1Internal Medicine, Royal College of Physicians of Ireland, and Taibah University, Dublin, and Madina, Ireland, and Saudi Arabia
  2. 2Department of Ophthalmology, Mater Misericordiae University Hospital, Dublin, Ireland
  3. 3Endocrine, Connolly Hospital Blanchardstown, and Royal College of Surgeon in Ireland, Dublin, Ireland
  1. Correspondence to Dr Ruaa Abdullah Mansi; ruaa.mansi{at}


In this report, we present a case of a patient with a 30-year history of orbital asymmetry who presented with metastatic human epidermal growth factor receptor 2 (HER2) positive lacrimal/salivary gland ductal adenocarcinoma. The patient was treated with chemoradiotherapy and trastuzumab. Tumours of lacrimal gland origin are rare, and unfortunately can frequently present in late stage. There are no current guidelines on the optimal treatment of metastatic lacrimal gland tumours, in particular those with HER2 amplified malignancy. This case highlights a unique presentation of a rare disease, and the potential for targeted therapy.

  • Cancer intervention
  • Eye
  • Interventional radiology
  • Palliative care
  • Head and neck cancer

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Contributors RAM, BM, TF and JM were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content. RAM, BM, TF and JM gave final approval of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.