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Case Reports: Findings that shed new light on the possible pathogenesis of a disease
Androgen receptor amplification in mesonephric remnants
  1. Gulnaz Siddiqui1,
  2. Alexandra Zara Rozalen2 and
  3. Victor E Nava2,3
  1. 1Department of Biomedical Sciences, University of Missouri Kansas City, Kansas City, Missouri, USA
  2. 2Department of Pathology, Washington DC VA Medical Center, Washington, District of Columbia, USA
  3. 3Department of Pathology, The George Washington University, Washington, District of Columbia, USA
  1. Correspondence to Dr Victor E Nava; vnava1{at}gwu.edu

Abstract

Mesonephric remnants (MRs) are embryonic vestiges most commonly found in female pathology specimens from the lateral wall of the cervix. The highly regulated genetic programme of mesonephric duct development has been well characterised in animals based on traditional surgical castration and knockout mouse experiments. However, the process is incompletely understood in humans. MRs are believed to give rise to mesonephric neoplasms, which are rare tumours with uncertain pathophysiology. There is a dearth of molecular studies on mesonephric neoplasms in part due to their rarity. Here, we report the results of next-generation sequencing of MR, which identified amplification of the androgen receptor gene for the first time to the best of our knowledge and discuss the potential implications in the context of the literature.

  • Pathology
  • Obstetrics and gynaecology

http://dx.doi.org/10.1136/bcr-2022-251741

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    Footnotes

    • Contributors GS wrote the first draft and edited additional versions. AZ contributed to the clinical and pathologic diagnosis and edited the manuscript. VEN designed the study, took micrographs and edited the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.