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Corneal squamous neoplasia: masquerades and management outcomes at a rural eyecare centre
  1. Ayushi Agarwal1,
  2. Swathi Kaliki1 and
  3. Somasheila I Murthy2
  1. 1Ocular Oncology Services, The Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, Telangana, India
  2. 2The Shantilal Shanghvi Cornea Institute, LV Prasad Eye Institute, Hyderabad, Telangana, India
  1. Correspondence to Dr Somasheila I Murthy; smurthy{at}


The authors describe two cases of corneal ocular surface squamous neoplasia (OSSN), presenting at our rural eyecare centre, which were initially misdiagnosed as viral epithelial keratitis and corneal pannus with focal limbal stem cell deficiency. Both the cases were refractory to initial treatment and corneal OSSN was suspected. Anterior segment-optical coherence tomography (AS-OCT) revealed a thickened, hyper-reflective epithelium with abrupt transition and an underlying cleavage plane, features typical of OSSN. Topical 1% 5-fluorouracil (5-FU) therapy was initiated and in two cycles (first case) to three cycles (second case), complete resolution was noted both clinically and on AS-OCT, with no significant side effects. Both patients are currently free of tumour at the 2-month follow-up period. The authors report the rare, atypical presentations of corneal OSSN, discuss the masquerades and highlight the role of primary topical 5-FU in managing corneal OSSN in limited resource settings.

  • Oncology
  • Ophthalmology

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  • Contributors All authors contributed to the intellectual content of the article and the finalisation of the images. AA drafted the manuscript. SIM and SK revised and finalised the manuscript. All authors take full responsibility for the integrity and content of the article. All authors were involved in managing the patient and gave final approval of the manuscript.

  • Funding This study was funded by Hyderabad Eye Research Foundation (LCE-BHR-R-12-22-976).

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.