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Metastatic signet-ring carcinoma to the uterus presenting as an endometrial polyp
  1. Ramzi Amin1,
  2. Carly Yanlin Wu1,
  3. Jill Cheng Sim Lee2 and
  4. Mihir Gudi Ananta3
  1. 1Department of Histopathology, KK Women's and Children's Hospital, Singapore
  2. 2Department of Obstetric and Gynaecology, KK Women's and Children's Hospital, Singapore
  3. 3Pathology, KK Women's and Children's Hospital, Singapore
  1. Correspondence to Dr Ramzi Amin; ramzidhmamin{at}


Primary signet-ring cell carcinoma of the uterus is rare and requires exclusion of possible metastatic tumour to the uterus. We report a case of a woman in her 70s who underwent hysteroscopy and a polypectomy for a polyp arising from the uterine wall. On histological examination, malignant cells with signet-ring cell morphology were found within the fragments of endometrial tissue. Immunohistochemical studies indicated a metastatic adenocarcinoma possibly from the gastrointestinal tract. Additional radiological investigations revealed a possible primary gastric tumour, which was further confirmed on subsequent biopsies. This case illustrates that gastric carcinomas can rarely metastasise to the endometrium and highlights the importance of clinical correlation in arriving at the final diagnosis.

  • Pathology
  • Gastric cancer
  • Cancer - see Oncology

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  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content—CYW, JCSL, RA and MGA. The following authors gave final approval of the manuscript—CYW, JCSL, RA and MGA.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.