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  • Blastic plasmacytoid dendritic cell neoplasm in an adolescent female: a rare entity with challenging diagnosis and management

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Case Reports: Rare disease
Blastic plasmacytoid dendritic cell neoplasm in an adolescent female: a rare entity with challenging diagnosis and management
  1. Ankit Agarwal1,
  2. Michelle Amit1,
  3. Joanna Chaffin2 and
  4. Amanda Strobel3
  1. 1Pediatrics, Ascension Sacred Heart Hospital Pensacola, Pensacola, Florida, USA
  2. 2Department of Pathology, University of Florida, Gainesville, Florida, USA
  3. 3Pediatric Hematology/Oncology, University of Florida, Pensacola, Florida, USA
  1. Correspondence to Dr Amanda Strobel; astrobel{at}ufl.edu

Abstract

Blastic plasmacytoid dendritic cell neoplasm is a rare and aggressive haematopoietic neoplasm with poor prognosis. It usually presents with cutaneous lesions and symptoms secondary to bone marrow involvement. Due to rarity and lack of standard treatment protocols, these cases are difficult to diagnose and treat. We report a case of a female in early adolescence who presented with skin nodules on the leg. The diagnosis was established by immunophenotypic studies. We discuss the investigations and treatment options available to diagnose and treat this malignancy.

  • Paediatric oncology
  • Chemotherapy

http://dx.doi.org/10.1136/bcr-2022-254008

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    Footnotes

    • Contributors AA and MA prepared the original manuscript. AS and JC contributed to the critical review of the manuscript. JC provided histopathology and immunohistochemistry images. All the authors have read and approved the final version of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.