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Aggressive giant cell lesion of mandible–confusing to common: true neoplasm versus reactive lesion
  1. Santha Devy Arumugam1,
  2. Bharathraj Kanniyappan2,
  3. Umamaheswari Giri1 and
  4. Sivaramakrishnan Muthanandam1
  1. 1Oral & Maxillofacial Pathology and Oral Microbiology, Sri Balaji Vidyapeeth University, Pondicherry, India
  2. 2Oral & Maxillofacial Surgery, Sri Balaji Vidyapeeth University, Pondicherry, Puducherry, India
  1. Correspondence to Dr Santha Devy Arumugam; drsantha73{at}


Destructive lesions in the craniofacial region especially in the jawbones, if associated with giant cells, include a spectrum of lesions that pose difficulty in diagnosis. The nature of such a lesion in the jawbones is questionable about whether it is a reactive/benign lesion or aggressive/non-aggressive. Clinical, radiological and histopathological correlation may be a reliable indicator to differentiate between the qualities of the lesion, which directly accounts for effective and individual planning of the treatment. Here we present a case of a woman in her late 20s with an unusual destructive lesion of the mandible.

  • Dentistry and oral medicine
  • Radiology (diagnostics)
  • Surgical diagnostic tests

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  • Contributors UG and BK gathered the clinical data including the photograph after gaining written consent from the patient. SDA and UG contributed equally to writing the paper following planning, researching and interpreting the results. Hence, SDA is considered as the first author. BK, UG and SM contributed to writing the paper, editing, optimising the image and submitting the paper.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.