Article Text
Case Reports: Novel treatment (new drug/interventions; established drug/procedure in new situation)
Metastatic HER2-amplified non-small-cell lung cancer treated with trastuzumab deruxtecan
Abstract
Human epidermal growth factor receptor 2 (HER2) alterations can occur as gene mutations, gene amplification or protein overexpression. DESTINY-Lung01 and DESTINY-Lung02 demonstrated the efficacy of trastuzumab deruxtecan in the subsequent line setting in patients with unresectable or metastatic HER2-mutated non-small-cell lung cancer (NSCLC). Trastuzumab deruxtecan has not been studied in select patients with HER2-amplified NSCLC. Here, we present the first reported case of metastatic HER2-amplified NSCLC treated with trastuzumab deruxtecan with a durable response to therapy.
- Lung cancer (oncology)
- Therapeutic indications