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  • Primary gastric amyloidosis associated with linitis plastica and delayed progression to systemic amyloidosis and multiple myeloma

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Case Reports: Unusual association of diseases/symptoms
Primary gastric amyloidosis associated with linitis plastica and delayed progression to systemic amyloidosis and multiple myeloma
  1. Georges Khalil1,
  2. Dimitri Fiani2,
  3. Fares Antaki3 and
  4. Ernest Diab4
  1. 1Department of Internal Medicine, Saint John Hospital, Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, Beirut, Lebanon
  2. 2Department of Internal Medicine, Universite Saint-Joseph Faculte de medecine, Beirut, Lebanon
  3. 3Ophthalmology, Centre Hospitalier Universitaire de l'Universite de Montreal, Montreal, Quebec, Canada
  4. 4Department of Hematology-Oncology, Universite Saint-Joseph Faculte de medecine, Beirut, Lebanon
  1. Correspondence to Dr Ernest Diab; ernest.diab95{at}gmail.com

Abstract

We report the case of a woman in her 50s who underwent, 5 years prior, a total gastrectomy after neoadjuvant chemotherapy for diffuse-type gastric cancer diagnosed during a workup for isolated gastric primary light chain (AL) amyloidosis. At the time of diagnosis, immunoglobulins light chain measurements and bone marrow biopsy were performed to rule out multiple myeloma and came back normal. Three years later, the patient developed systemic amyloidosis involving the heart and the lungs, after which she developed multiple myeloma. Isolated amyloid deposits in the stomach are a rare finding. While AL amyloidosis is frequently found in concomitance with multiple myeloma, late progression of primary AL amyloidosis to systemic amyloidosis and multiple myeloma is uncommon.

  • Cancer - see Oncology
  • Gastric cancer
  • Pathology

http://dx.doi.org/10.1136/bcr-2022-252786

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    Footnotes

    • Twitter @FaresAntaki

    • GK, DF and ED contributed equally.

    • Contributors GK: design of study, initiation of study and provided revisions to scientific content of manuscript. ED: design of study, initiation of study, draft writing and paper reviewing. DF: design of study, initiation of study, draft writing and paper reviewing. FA: design of study, initiation of study, provided stylistic/grammatical revisions to manuscript and figure creation.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.