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Examining the differential of digital ischaemia and review of paraneoplastic ischaemia
  1. Lauran Zeineddine1 and
  2. Diana Gomez-Manjarres2
  1. 1Internal Medicine, University of Florida, Gainesville, Florida, USA
  2. 2Pulmonary and Critical Care Medicine, University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr Lauran Zeineddine; lzeinedd{at}


There is a broad differential diagnosis of digital ischaemia that includes commonly encountered conditions of vascular or thromboembolic nature as well as less commonly seen such as those of vasculitic or rheumatological origin. A less frequently encountered pathology is digital ischaemia associated with malignancy. This paraneoplastic process is rare and infrequently described in the literature, though it has been observed in various solid and haematological malignancies. Here, we describe a patient case with an atypical presentation of digital ischaemia and present a brief review on prior reports of digital ischaemia related to cancer.

  • Venous thromboembolism
  • General practice / family medicine
  • Haematology (incl blood transfusion)
  • Oncology
  • Lung cancer (oncology)

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  • Contributors Authors LZ and DG-M both participated equally in the writing and revising of the manuscript and selection of images presented within the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.