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Anal canal gastrointestinal stromal tumour (GIST)
  1. Francesco Brucchi1,
  2. Sara Lauricella2,
  3. Luca Bottero3 and
  4. Giuseppe Giacomo Faillace2
  1. 1General Surgery Residency Program, University of Milan, Milan, Milano, Italy
  2. 2Department of Surgery, Ospedale Citta' di Sesto San Giovanni, Sesto San Giovanni, Lombardia, Italy
  3. 3Department of Surgery, Ospedale Bassini, Cinisello Balsamo, Lombardia, Italy
  1. Correspondence to Dr Francesco Brucchi; brucchi.francesco{at}


Gastrointestinal stromal tumours (GISTs) are malignant mesenchymal tumours that originate from the interstitial pacemaker cells of Cajal. They are particularly rare, comprising only 5% of all GISTs, and often present at an advanced stage. Treatment for these tumours is still a topic of debate due to their low incidence and insidious location. A woman in her mid-70s presented with rectal bleeding and anal discomfort. A 4.5×4 cm anal GIST was diagnosed. A local excision was performed and the patient was further treated with tyrosine kinase inhibitors. At a 6-month follow-up, the MRI showed that she was disease free. Anorectal GISTs are unusual and tend to be aggressive. Surgical resection is the first-line treatment for primary, localised GISTs. However, the appropriate surgical technique for these tumours is still a topic of debate. Further studies are needed to fully understand the oncologic behaviour of these rare neoplasms.

  • Colon cancer
  • Gastrointestinal surgery
  • General surgery
  • Surgical oncology

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  • Contributors FB and SL: wrote the paper. LB: data collection and analysis. GGF: supervised the findings of this work.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.