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Oedema: a rare complication of plasma donation in an adolescent female
  1. Elahe Meryl Shychuk1,
  2. Krystal Glasford2,
  3. Andrew Jacob Shychuk3 and
  4. Nancy Joseph1
  1. 1Pediatrics, University of Florida College of Medicine, Gainesville, Florida, USA
  2. 2College of Medicine, University of Florida, Gainesville, Florida, USA
  3. 3Internal Medicine, University of Florida, Gainesville, Florida, USA
  1. Correspondence to Dr. Elahe Meryl Shychuk; mshychuk{at}


Plasma donation has been widely used to recover medically vital components, such as immunoglobulins and clotting factors. Although generally well tolerated, there have been reports in the medical literature of reactions following blood and plasma donation. We present the first case, to our knowledge, of lower extremity oedema as the only complication noted following plasma donation in an adolescent female without underlying risk factors. Laboratory evaluation was unremarkable with the exception of decreased total serum protein. Symptoms resolved with conservative management and avoidance of plasma donation. Our case highlights the importance of screening for all sources of income in adolescents to assess for health disparities, evaluate risk factors and provide appropriate guidance.

  • Paediatrics (drugs and medicines)
  • General practice / family medicine
  • Medical management
  • Diet
  • Preventative pediatrics

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  • Contributors KG and EMS, AS and NJ made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data for the work. NJ, EMS and AS contributed to drafting the work or revising it critically for important intellectual content. KG and EMS, AS and NJ made final approval of the version to be published. KG and EMS, AS and NJ agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.