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Successful outcome in a compound heterozygote haemoglobin E/beta-thalassaemia in pregnancy


Haemoglobin E (HbE) affects at least 1 million people around the world. The carrier frequency of HbE/beta-thalassaemia (HbE/β-thalassaemia) is highest in Southeast Asia. In India, the highest frequency is observed in the northeast region. Distinguishing between homozygous HbE disease and HbE/β-thalassaemia is a challenge to the haematopathologist as well as to the treating obstetrician because both are clinically and haematologically similar, posing a difficulty in managing anaemia and assessing the fetal risk for the same disease. This article reports a case of compound heterozygote HbE/β-thalassaemia in pregnancy and its successful outcome.

  • haematology (drugs and medicines)
  • obstetrics, gynaecology and fertility
  • genetics
  • genetic screening / counselling
  • haematology (incl blood transfusion)

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