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  • Advanced enteropathy-associated T cell lymphoma (EATL) presenting with severe malabsorption and concomitantly diagnosed coeliac disease (CD)

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Oncology
Advanced enteropathy-associated T cell lymphoma (EATL) presenting with severe malabsorption and concomitantly diagnosed coeliac disease (CD)
  1. Anjali Rajagopal1,
  2. Carrie A Thompson2,
  3. Allison K Chorzempa3 and
  4. Alexander J Ryu3
  1. 1Department of Medicine, AI & Innovation, Mayo Clinic, Rochester, Minnesota, USA
  2. 2Division of Hematology, Mayo Clinic Rochester, Rochester, Minnesota, USA
  3. 3Division of Hospital Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Anjali Rajagopal; rajagopal.anjali{at}mayo.edu

Abstract

Enteropathy-associated T cell lymphoma (EATL) is an aggressive subtype of non-Hodgkin’s lymphoma often associated with coeliac disease (CD). We describe a previously healthy man in his 50 s who presented with a history of abdominal pain, failure to thrive and significant weight loss over a 3-month period. Investigations revealed a positive coeliac serology, diffuse duodenal atrophy with multiple duodenal and jejunal ulcers on endoscopy and mesenteric lymphadenopathy on CT imaging. Duodenal tissue biopsy confirmed a diagnosis of EATL Stage IVB. Chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone regimen was initiated. This case highlights the need for greater awareness and consideration of EATL in individuals with worsening malabsorption and abdominal pain, irrespective of coeliac history.

  • Gastroenterology
  • Small intestine cancer
  • Oncology
  • Carcinogenesis
  • Coeliac disease

https://doi.org/10.1136/bcr-2023-258265

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    Footnotes

    • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms and critical revision for important intellectual content: AR, AJR, AKC and CAT. The following authors gave final approval of the manuscript: AJR and CAT.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.