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Uterine carcinosarcoma showing immature teratoid-like differentiation
  1. Mio Naito1,
  2. Mika Terasaki2,
  3. Nozomi Ouchi1 and
  4. Masafumi Toyoshima1
  1. 1Obstetrics and Gynecology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
  2. 2Analytic Human Pathology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
  1. Correspondence to Dr Masafumi Toyoshima; m-toyoshima{at}


A carcinosarcoma is a rare form of cancer characterised by the presence of both carcinomatous and sarcomatous components. Here, we present our experience with an extremely rare case of an uterine carcinosarcoma with immature teratoid-like differentiation. The patient was a woman in her 60s. She was referred for the evaluation of a uterine tumour. She underwent total abdominal hysterectomy with bilateral adnexectomy and received postoperative treatment with paclitaxel and carboplatin. On microscopic examination, the tumour had a heterogeneous appearance with a combination of carcinomatous and sarcomatous elements, and teratoid features. The tumour included immature squamous epithelial cells and immature epithelial glands, and focal atypical fused glands, which are consistent with endometrioid carcinoma, were identified in the endometrium. Pathological differentiation from extrarenal Wilms’ tumour and teratocarcinosarcoma was challenging. The final pathological diagnosis was uterine carcinosarcoma with immature teratoid-like differentiation. At 14 months after the surgery, the patient has not experienced recurrence.

  • Cancer - see Oncology
  • Pathology

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  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms and critical revision for important intellectual content: MN, MiT, NO, MaT. The following authors gave final approval of the manuscript: MaT.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.