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Gastrointestinal stromal tumour-induced hypercalcaemia
  1. Nicola Trotter1 and
  2. Jeff White2
  1. 1Internal Medicine, NHS Greater Glasgow and Clyde, Glasgow, UK
  2. 2Medical Oncology, Beatson West of Scotland Cancer Centre, Glasgow, UK
  1. Correspondence to Dr Nicola Trotter; nicola.trotter{at}


Hypercalcaemia is recognised as the most common oncological metabolic emergency, with several proposed underlying mechanisms. Nevertheless, hypercalcaemia has been rarely reported as a complication in patients with gastrointestinal stromal tumours (GISTs). GISTs are uncommon mesenchymal tumours of the gastrointestinal tract. There are only nine previous cases of hypercalcaemia occurring in patients with GIST reported in the literature. We report a case of a man in his 70s with a background of metastatic GIST on fourth-line treatment. The patient presented with new hypercalcaemia and acute kidney injury. Despite medical management, his calcium remained elevated and he deteriorated secondary to significant disease progression.

  • Calcium and bone
  • Gastric cancer

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  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content—NT and JW. The following authors gave final approval of the manuscript—NT and JW.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.