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Urology
Locally advanced solitary fibrous tumour of the prostate
  1. Eric Wahlstedt1,
  2. Christopher Zhou2,
  3. Sydney Strup1,
  4. Joon Kyung Kim3,
  5. Stephen E Strup1,
  6. Leonard Yenwong3,
  7. Derek B Allison1,3 and
  8. Patrick J Hensley1,3
  1. 1Department of Urology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
  2. 2School of Medicine, Case Western Reserve University, Cleveland, OH, USA
  3. 3Department of Pathology, University of Kentucky College of Medicine, Lexington, Kentucky, USA
  1. Correspondence to Dr Patrick J Hensley; patrick.hensley{at}uky.edu

Abstract

Solitary fibrous tumours (SFTs) are rare mesenchymal neoplasms composed of spindle cells, most often occurring in the pleura. SFTs arising from the prostate are exceptionally rare, with only around 40 cases reported in literature to date. We report a man in his 60s who was referred to our clinic for elevated prostate-specific antigen and presented with mild obstructive lower urinary tract and defecatory symptoms. Prostate needle-core biopsy revealed neoplastic spindle cells that strongly expressed CD34. Cross-sectional imaging demonstrated a 12 cm locally advanced heterogeneous prostate mass with intravesical extension and mass effect on the anterior rectum. Radical cystoprostatectomy with orthotopic neobladder reconstruction was performed, and the diagnosis of primary prostatic SFT was made based on histological characteristics and immunophenotyping. We present diagnostic, clinical management and prognostic considerations in patients with primary prostatic SFT.

  • Prostate
  • Urology
  • Urological surgery
  • Pathology

https://doi.org/10.1136/bcr-2023-257666

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    Footnotes

    • Contributors EW, Christopher Zhou, SS and Joon Kim drafted the initial manuscript including the abstract, introduction, case report, discussion and conclusion. PH, DBA and SS assisted in editing the manuscript. DBA and Leonard Yenwong compiled pathological and gross images and helped to write pathological and histological sections of the case report.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.