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Saccular posterior cerebral artery aneurysm encased within a lipoma
  1. Calvin Wing Hang Chin,
  2. Barry Ting Sheen Kweh and
  3. Augusto Gonzalvo
  1. Neurosurgery, Austin Health, Heidelberg, Victoria, Australia
  1. Correspondence to Dr Calvin Wing Hang Chin; chin.cwh{at}


We present a case of a man in his 80s with an incidental posterior cerebral artery aneurysm encased within a lipoma. The literature surrounding the incidence and intricate relationship of lipomas to cerebral aneurysms is reviewed. Lipomas are proposed to be derived from maldifferentiated subarachnoid space. For this reason, lipomas are often associated with vascular malformations and may develop in conjunction with vascular malformations such as cerebral aneurysms. Hypothesised theories include the impediment of smooth muscle nutrient diffusion and the secretion of factors that weaken the arterial wall thereby predisposing to aneurysm formation. When lipomas neighbour cerebral vasculature, careful evaluation of the adjacent vessels should be conducted.

  • Neurology
  • Stroke
  • Neuroimaging
  • Neurosurgery

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Intracranial lipomas are rare and usually asymptomatic congenital malformations1 commonly associated with brain malformations, as well as cerebral artery abnormalities.2

We present the first report in English literature of a patient with a posterior cerebral artery aneurysm encased by a lipoma within the interpeduncular fossa. The association of intracranial lipomas with cerebral artery abnormalities and its possible pathogenesis is discussed.

Case presentation

A man in his 80s presented with a long-standing history of a persistent synchronous resting head and hand tremor. This was associated with a mild cervical dystonia. He did not have comorbidities that increased the risk of aneurysm such as smoking, hypertension, nor a family history of aneurysms or connective tissue disorders. He was otherwise well and had no other neurological symptoms. On clinical examination, this tremor ameliorated with posturing of the hands, did not resemble a Parkinsonian tremor and did not have a postural nor intention component. No other neurological abnormalities were revealed on examination.


A time-of-flight MR angiogram of the brain (figure 1) and a subsequent CT angiogram (figure 2) performed 2 weeks later found a saccular proximal left posterior cerebral artery aneurysm measuring 7×4 mm in diameter within the interpeduncular fossa, partially encased within a T1 hyperintense lipoma 13 mm in diameter. There was no evidence of cortical dysplasia or other aneurysms on either modality of imaging.

Figure 1

MRI showing a lipoma(blue arrow) within the interpeduncular fossa, hyperintense on T1 imaging (A) and time-of-flight angiography (B) showing a left posterior cerebral artery aneurysm 7×4 mm in diameter, partially encased by the lipoma(blue arrow).

Figure 2

CT images with showing the aneurysm(blue arrow) measuring 7×4 mm partially encased by a lipoma (A). Three-dimensional reconstruction of the arterial phase study (B) shows the saccular aneurysm(blue arrow)

Differential diagnosis

Given the congenital aetiology of intracranial lipomas, the lesion was deemed incidental and likely to have been present for many years. The possibility of the lipoma causing compression on the cerebral peduncles or midbrain causing this tremor was considered. However, given that this man shared similar symptoms with a sibling, and the clinical findings did not convincingly resemble a rubral nor a cerebellar outflow tremor, this tremor syndrome was assumed more likely to be congenital.

Outcome and follow-up

After multidisciplinary discussion, it was deemed reasonable to continue conservative management with surveillance. The patient remains in good health at 6 months from diagnosis with no new symptoms, no limitations to his daily activities, nor any modifiable risk factors. An interval CT angiogram of the brain was performed at 12 months from diagnosis to assess for aneurysm growth and the subsequent risk of rupture as suggested by Thompson et al3—this was stable.


Intracranial lipomas are typically asymptomatic lesions. However, when symptomatic they usually result in headaches, seizures, psychomotor retardation and/or cranial nerve deficits.4

These lesions are associated with brain malformations in 55% of cases5 and dysgenesis of the corpus callosum is most common. They are presumably of dysembryological rather than neoplastic origin and rare, with incidence estimated at 0.06%–0.46%1 and a high proportion of cases tending to be located in the midline cerebral structures.6 In Truwit et al’s study of 42 patients with intracranial lipomas,1 45% were classified as interhemispheric, 25% quadrigeminal/superior cerebellar and 14% suprasellar/interpeduncular. Yildiz et al’s study of 24 patients similarly observes the interpeduncular region to be the rarest location.7

Fusiform aneurysms are not rare in their association with intracranial lipomas, particularly those that are pericallosal. Eldevik and Gabrielsen8 reviewed 22 cases of pericallosal lipomas in the literature with 19 demonstrating fusiform aneurysmal dilatation on cerebral angiography. In our review of cases reported in English literature (table 1), there were eight cases of saccular aneurysms associated with lipomas, two of which were non-contiguous. Of these, six involved the middle cerebral artery, and four of these involved a lipoma in the sylvian fissure. None involved the posterior cerebral artery.

Table 1

Reported cases of cerebral aneurysms associated with lipomas in English literature. mean age 50, median age 27

The embryological pathogenesis of intracranial lipomas may be the result of abnormal persistence and maldifferentiation of the meninx, as theorised by Verga in 19299 and supported by Truwit’s study of 42 patients with intracranial lipomas.1 Lipomas are, therefore, considered maldifferentiated subarachnoid space rather than true neoplasms. They may interfere with the growth of cortical tissue and result in local cortical dysplasia,1 10–12 explaining the high proportion of associated cerebral hypoplasias. Intracranial lipomas have been reported in association with accompanying cortical dysplasia and vascular malformations(ie, dilated abnormal feeder arteries with abnormal venous drainage surrounding the lipoma) that may represent tumour vasculature or cortical dysplasia.10 11 13

As an intracranial lipoma represents maldifferentiated subarachnoid space, it is not unexpected for it to be traversed by neurovasculature.1 Futami et al14 hypothesised several theories for the pathogenesis of a concurrent aneurysm. The development of a congenital lipoma may be concurrent with a congenital structural deficiency within the cerebral arterial wall, contributing to an increased likelihood of aneurysm formation. On the basis of Zervas et al’s15 theory that cerebrovascular smooth muscle relies on the diffusion of nutrients via the cerebrospinal fluid in the subarachnoid space due to the absence of vasa vasorum, it is possible that a contiguous lipoma impedes this process in the adjacent arterial wall.14 Lipomas may also secrete factors that weaken the arterial wall.14 It should be noted that as of yet there has not been a suitable theory presented to link intracranial lipomas to the formation of a non-contiguous aneurysm, although they have been reported.7 16

Our case involved the posterior cerebral artery, a rare site for non-lipoma associated aneurysms,5 which may be explained by variations in vessel size and haemodynamics.17 On the basis that lipomas may contribute to the development of a contiguous aneurysm15 18, the rarity of posterior cerebral aneurysms associated with lipomas may also be attributable to the low incidence of interpeduncular lipomas.

Small intracranial lipomas smaller than 5 mm may be difficult to differentiate from aneurysms in time-of-flight MR angiography and may need correlation with fat-suppressed imaging or CT imaging.19 The possibility of an underlying vascular abnormality should be evaluated given their association, and if doubt persists, further imaging or invasive digital subtraction angiography should be considered. In our case, the appearance of the lesion on MR angiography coupled with CT angiography was sufficient to make a definitive diagnosis.7 High-resolution vessel wall imaging is a promising tool to assess vessel wall enhancement, an emerging biomarker for unstable cerebral aneurysms,20 through ‘black blood’ techniques.18 Current evidence supports its use in ruling out aneurysm instability,21 finding high sensitivity but mixed specificity. While not performed in our case, its use should be considered in such complex cases where the decision to treat or not requires careful consideration. Further novel imaging tools emerging to characterise aneurysms include 7 Tesla MRI, intravascular imaging, and four-dimensional imaging18

Intracranial lipomas rarely justify surgical management given that they are non-malignant, and most cases are asymptomatic. Tahmouresie et al’s review of 21 patients showed postoperative improvement in 23.8% and death in 47.6%.22 In these cases, the substantial risk of operative complications may be owed to adhesions to surrounding structures,23 calcification of the lipoma or surrounding structures,24 and hypervascularisation.25 26 Due to these operative complexities, in cases where an adjacent or encasing lipoma is expected to significantly limit access to an aneurysm for the purpose of clipping and definitive management is indicated, we would recommend an endovascular approach. Biopsy may be considered when the diagnosis is uncertain from imaging alone, and if excision is deemed necessary, it should be limited to partial removal.23

Intracranial aneurysms in the posterior circulation measuring 7–12 mm have a 5-year rupture rate of 14.5%.27 Risk factors for lifetime rupture aside from the size of the aneurysm include current smoking status (OR 3.05), female sex (OR 2.50) and the age at diagnosis of the unruptured intracranial aneurysm being less than 50 years old (OR 7.50).28 In the presence of a lipoma, there is no clear evidence for increased rupture risk—from our review of the literature and including our case, one out of nine cases of saccular aneurysms associated with a lipoma within the anterior circulation ruptured on presentation, and no aneurysms that were contiguous with the lipoma ruptured. The incidence of rupture on follow-up could not be concluded from these cases, and the proportion of aneurysms that present with rupture is not well described in the literature. However, given that the prevailing theories on its pathogenesis may support an ongoing theoretical risk for further wall weakening, it is reasonable to exercise caution by performing vessel wall imaging and following up earlier than usual to establish whether the aneurysm is growing. Similarly, there is insufficient evidence to recommend earlier treatment compared with isolated aneurysms. The decision to treat an aneurysm, whether endovascularly or with microsurgical clipping, is a risk versus benefits decision usually made in conjunction with the patient. In this case, the aneurysm being encased within the lipoma would increase the operative complexity if being accessed by microsurgical means. On one hand, the patient had several predictors of poor endovascular outcome including an age greater than 50 and the location of the aneurysm being in the posterior circulation.27 On the other hand, it is important to acknowledge this patient’s age, the borderline size of the aneurysm and paucity of other risk factors for rupture. Additionally, the lipoma wrapping the aneurysm itself may provide a degree of protection against subarachnoid haemorrhage. On balance, it was deemed reasonable to conservatively manage his aneurysm.

Patient’s perspective

Consulting my GP, he observed an increased tremors of both hands and my head. Concerned that the tremors might be early indicators of Parkinsons disease, he referred me to a neurologist for some testing. Examining the resulting MRI, it showed a cerebral artery aneurysm. The neurologist sent the MRI to a neurosurgeon to seek another opinion. Both agreed that the aneurysm had a lipoma surrounding it and that it could have been there for many years and that it is unlikely to burst. Being 80 and relatively active, a non-smoker and having a long history of normal blood pressure, I think the chance of the aneurysm bursting is very low. I am due for a second scan 12 months after the first one and I am confident that the result will show that the aneurysm is the same size.

Learning points

  • Intracranial lipomas are benign and often associated with vascular malformations and aneurysms.

  • On discovering an intracranial lipoma, an underlying vascular abnormality should be considered due to their association.

  • Intracranial lipomas smaller than 5 mm may be difficult to differentiate from aneurysms in time-of-flight MR angiography and may need correlation with fat suppressed imaging, CT or invasive digital subtraction angiography.

  • Isolated intracranial lipomas carry a substantial operative risk and rarely justify operative management when asymptomatic.

  • When associated with an aneurysm, however, the annual rupture risk should be considered with the operative complexity. Posterior circulation aneurysms carry both a higher annual risk of rupture and a poorer rate of endovascular outcomes.

Ethics statements

Patient consent for publication


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  • Contributors The following authors were responsible for drafting of the text, sourcing and editing of clinical images, investigation results, drawing original diagrams and algorithms, and critical revision for important intellectual content: CWHC and BTSK. The following author gave final approval of the manuscript: AG.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.