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Case Reports: Novel treatment (new drug/interventions; established drug/procedure in new situation)
Extraskeletal myxoid chondrosarcoma in the pelvis successfully treated with proton beam radiotherapy
  1. Yosuke Honda1,2,
  2. Hirohisa Katagiri2,
  3. Tsuyoshi Onoe3 and
  4. Takeshi Aramaki4
  1. 1Orthopedics, Hamamatsu Red Cross Hospital, Hamamatsu, Shizuoka, Japan
  2. 2Orthopedic Oncology, Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan
  3. 3Radiation and Proton Therapy, Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan
  4. 4Interventional Radiology, Shizuoka Cancer Center, Sunto-gun, Shizuoka, Japan
  1. Correspondence to Dr Hirohisa Katagiri; h.katagiri{at}scchr.jp

Abstract

The standard treatment for extraskeletal myxoid chondrosarcoma is wide excision. However, extraskeletal myxoid chondrosarcoma is often located in the deep layers of the extremities and pelvis, so functional impairment due to wide resection is unavoidable in many cases. In addition, the efficacy of radiotherapy and chemotherapy has not been defined, so no treatment method is established for unresectable cases. Here we report a case involving a man in his late 60s with extraskeletal myxoid chondrosarcoma of the pelvis who responded to proton beam radiotherapy with intra-arterial chemotherapy and did not require surgery. The patient maintained a complete response for more than 7 years. The findings from this case suggest that definitive irradiation can be an alternative to wide resection for cases of extraskeletal myxoid chondrosarcoma in which severe disability cannot be avoided after resection or when the tumour is inoperable due to its size and location.

  • Radiotherapy
  • Orthopaedics

http://dx.doi.org/10.1136/bcr-2022-250218

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    Footnotes

    • Contributors YH was involved in the patient’s treatment, drafted this manuscript and obtained written consent from the patient. HK was the consultant in charge and was involved in the patient’s treatment and in editing the manuscript. TA was involved in the patient’s interventional radiology treatment. TO planned and implemented the patient’s radiation therapy.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.