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Differentiation of hydrochlorothiazide-induced dermatitis from stasis dermatitis
  1. Rewan Abdelwahab1,
  2. Eric G Tangalos2 and
  3. John Matulis2
  1. 1Community Internal Medicine, Mayo Medical School, Rochester, Minnesota, USA
  2. 2Community Internal Medicine, Mayo Clinic Minnesota, Rochester, Minnesota, USA
  1. Correspondence to Dr John Matulis; Matulis.John{at}


A woman in her 60s with a history of hypertension and stasis dermatitis presented to a primary care clinic with a bilateral, erythematous rash on the legs, stomach, and chest. Photosensitive rash and dermatitis may be caused by many conditions. Hydrochlorothiazide-induced dermatitis is a rare side effect of thiazide diuretics. Early identification of sulfa-sensitivity and photoallergic or phototoxic reaction is essential to accurate diagnosis and treatment of photosensitive dermatitis. Soliciting a targeted history is essential to delineating drug-induced dermatitis from stasis dermatitis. A thorough skin examination can elucidate the focal or extensive nature of the rash and is essential to making an accurate diagnosis. Immediate cessation of hydrochlorothiazide and switching drugs classes for hypertension management typically leads to resolution of symptoms.

  • Hypertension
  • Dermatology
  • Cardiovascular system
  • Contraindications and precautions
  • Medical management

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  • Contributors RA drafted the article and followed the patient’s case. EGT took the pictures, edited the article and followed the patient’s case. JM followed the patient’s case, edited the article and approved the final version of this manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.