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SMART syndrome: two cases highlighting a complex and rare complication of brain irradiation


Stroke-like migraine attacks after radiation therapy (SMART) syndrome is a rare complication of radiotherapy with complex neurological impairment. Patients present with neurological symptoms and signs such as migraine, hemianopsia, hemiplegia, aphasia and/or seizures—without recurrence of neoplastic disease. In this report, we describe SMART syndrome in two adult patients 4 and 14 years following brain irradiation, respectively.

  • neurooncology
  • neuroimaging
  • CNS cancer
  • radiotherapy

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