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Non-surgical management of a large periapical lesion with internal resorption using PRF, hydroxyapatite and MTA
  1. Geetika Gupta,
  2. Abhilasha Agarwal,
  3. Afroz Alam Ansari and
  4. Rajeev Kumar Singh
  1. Department of Paediatric and Preventive Dentistry, King George Medical University, Lucknow, Uttar Pradesh, India
  1. Correspondence to Dr Abhilasha Agarwal; abhilasha08031994{at}


Periapical lesions of endodontic origin are caused by microbial infection of pulp. According to various studies, it is known that necrosis of pulp provides a favourable habitat for microbes to replicate and release various toxins into the periapical tissue leading to inflammation and formation of a periapical lesion. A variety of non-invasive methods to manage such lesions include conservative root canal treatment, aspiration-irrigation technique, decompression technique, calcium hydroxide therapy, lesion sterilisation and tissue repair therapy, and the apexum procedure. We present a case report describing non-surgical management of a large periapical lesion associated with a permanent central incisor displaying internal inflammatory resorption using platelet rich fibrin (PRF), bone graft and mineral trioxide aggregate (MTA).

  • Dentistry and oral medicine
  • Mouth

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  • Contributors Conception and design: GG and AA. Data collection: AA. Drafting of manuscript: GG and AA. Critical revision: AAA and GG. Final approval: RKS and AAA.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.