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Concomitant methimazole-induced agranulocytosis and cholestatic jaundice in a young woman
  1. Chris Alcorn,
  2. Prathayini Subarajan and
  3. Jay Anderson
  1. Medical Education, OhioHealth Riverside Methodist, Columbus, Ohio, USA
  1. Correspondence to Dr Jay Anderson; jay.anderson{at}ohiohealth.com

Abstract

A woman in her 30s presented to the emergency department with new-onset sore throat and fever. She had recently been diagnosed with Graves’ disease 3 months prior. As a result, she was initiated on atenolol and methimazole for management. Her methimazole dosing had been stable at 15 mg daily for the month prior to presentation. Investigation revealed severe neutropenia and jaundice. She was found to have concomitant agranulocytosis and cholestatic jaundice secondary to methimazole.

Methimazole was discontinued on admission and the patient received granulocyte colony-stimulating factor for an absolute neutrophil count (ANC) of zero. She was placed on broad-spectrum antibiotics and intravenous steroids for epiglottic and supraglottic oedema noted on bedside laryngoscopy. ANC and bilirubin improved over a 2-week hospital course. She was discharged on a temporary regimen of propranolol, dexamethasone and potassium iodide until she was able to undergo successful thyroidectomy for definitive management of Graves’ disease outpatient.

  • Thyroid disease
  • Pharmacology and therapeutics
  • Unwanted effects / adverse reactions
  • Hyperthyroidism

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Footnotes

  • Contributors CA is the primary author. He contributed the majority of the discussion, learning objectives, background and formatting. PS is the secondary author. She contributed the majority of the case presentation and summary. JA provided work in the presentation and editing throughout the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.