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Case Reports: Adverse drug reactions and complications
Choroidal effusion: a rare and unusual complication of daratumumab
  1. Aditi Singh1,
  2. Talal Bazzi2,
  3. Daniel Lebovic1 and
  4. Hakan Demirci3
  1. 1Hematology Oncology, Ascension St John Hospital, Detroit, Michigan, USA
  2. 2Internal Medicine, Ascension St John Hospital, Detroit, Michigan, USA
  3. 3W. K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan, USA
  1. Correspondence to Dr Aditi Singh; aditisingh0215{at}gmail.com

Abstract

Daratumumab-containing regimens are an effective treatment for advanced cases of multiple myeloma. Overall, daratumumab has a favourable safety profile, although rare side effects can occur. Rare side effects of daratumumab include choroidal effusion. Patients who begin to experience symptoms such as eye swelling, vision changes, eye discharge and blurry vision should undergo urgent ophthalmological evaluation and their daratumumab infusions held.

  • Haematology (drugs and medicines)
  • Immunological products and vaccines
  • Eye
  • Drugs and medicines
  • Cancer - see Oncology

http://dx.doi.org/10.1136/bcr-2022-249735

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    Footnotes

    • Contributors All of the listed authors have substantially contributed to revising the manuscript critically for important intellectual content. All authors have approved the manuscript that has been submitted for publication and agree to be accountable for all the aspects of the work reported in the case report. AS: conception of the idea, analysis and interpretation of the labs and imaging, and drafting the manuscript and literature review. TB: literature review and drafting the report. DL: analysis and interpretation of the labs and critical review of the draft. HD: conception of the idea, analysis and review of the ophthalmology examination and imaging, and critical review of the report.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.