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Case Reports: Rare disease
Sertoli-Leydig cell ovarian tumour: a rare cause of virilisation and androgenic alopecia
  1. Sriram Mudraje1,
  2. Sahana Shetty1,
  3. Shyamala Guruvare2 and
  4. Ranjini Kudva3
  1. 1Department of Endocrinology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
  2. 2Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
  3. 3Department of Pathology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India
  1. Correspondence to Dr Sahana Shetty; sahanashetty0606{at}gmail.com

Abstract

Sertoli-Leydig cell tumours (SLCTs) represent a rare cause of hyperandrogenic state. SLCTs are sex cord ovarian neoplasms, accounting for <0.2% of all ovarian tumours. Most of the sex cord-stromal tumours have a benign clinical course, with 10%–20% of them at risk of aggressive course. We report a case of a woman in her 30s who presented with androgenic alopecia, virilisation and secondary amenorrhoea. The evaluation revealed an extremely high testosterone level. Imaging for the localisation of source of excess testosterone with contrast-enhanced CT of the abdomen revealed a right ovarian mass. Hence, a diagnosis of testosterone-secreting ovarian tumour was considered. The patient underwent right salphingo-oophorectomy, and histopathology was reported as Sertoli cell tumour. Postoperatively, there was normalisation of serum testosterone levels with decrease in virilisation and resumption of spontaneous menstrual cycles. The patient conceived spontaneously after 2 months of surgery.

  • Obstetrics, gynaecology and fertility
  • Endocrinology

http://dx.doi.org/10.1136/bcr-2022-249324

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    Footnotes

    • Contributors SM wrote the manuscript under the supervision of SS. SS supported in collecting review articles and management plans. SG operated the case. RK provided a histopathology report. SM and SS contributed to the final version of the manuscript.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Case reports provide a valuable learning resource for the scientific community and can indicate areas of interest for future research. They should not be used in isolation to guide treatment choices or public health policy.

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.